By Allan Fox: Floyd Mayweather Jr. (49-0, 26 KOs) might only have one more shot at getting a big money rematch against Manny Pacquiao (57-6-2, 38 KOs) now that Pacquiao is talking about possibly retiring in early 2016. Pacquiao wants to put his concentration on being a senator in the Philippines.

Pacquiao, 36, still has win a seat in the senate in the upcoming May elections in the Philippines in 2016, but given his huge popularity, the chances are good that he’ll win the position.

“I think I’m ready [to retire]. I’ve been in boxing for more than 20 years,” Pacquiao said via ABS-CBN. “I prayed to God for guidance and I am happy about it.”

Mayweather defeated Pacquiao by a 12 round unanimous decision on May 2nd of this year in Las Vegas, Nevada at the MGM Grand. The fight gave Mayweather a guaranteed $200 million. Mayweather said that he made $300 million off the fight.

That’s a lot of money, and perhaps he’s not interested in facing Pacquiao a second time to get another big payday. But it doesn’t make much sense for Mayweather to come back and face anyone else other than Pacquiao if it means he’ll be losing out on making a lot more money against him. Mayweather’s guaranteed purse for his fight against Andre Berto last September was a little over $30 million.

If Mayweather comes back in 2016 to fight someone along the lines of Amir Khan, Danny Garcia, Shawn Porter and Keith Thurman, he likely won’t be getting much more than what he received for the Berto fight because those guys aren’t huge names in the United States with the casual boxing fans.

For Mayweather to make good money, he’s going to need to face Pacquiao, Miguel Cotto, Saul “Canelo” Alvarez or Gennady Golovkin. Those are all tougher fighters, but that’s what Mayweather will have to deal with if he wants the big money. The less risky fights pay a lot less than the risky ones.

“I will have to give up the other things that require my attention. If you are a senator, your focus should only be your job and your family,” Pacquiao told AFP.

The names that Pacquiao’s promoter Bob Arum is looking to put in with Pacquiao for his next and possible final fight in early 2016 are down to these names: Terence Crawford, Amir Khan, Juan Manuel Marquez and Kell Brook. Marquez’s name is still among the other names despite him saying he has no interest in fighting Pacquiao again. Arum could look to change Marquez’s mind. It will likely take a bigger offer to get him than it will for the other names.

If Arum is looking for the fighter that will bring the most money for Pacquiao, then he’ll select Marquez or Khan. If his focus is on helping to build one of his own Top Rank stars like Crawford, then we could see him get the fight, but it would likely bring Pacquiao less money than a fight against Marquez or Khan.

It’ll be interesting to see if Mayweather chooses to come back in 2016 and not fight Pacquiao a second time. Like Mayweather’s last fight, it’ll cost him a lot of money if he chooses not to pick the biggest name possible.